Professor and Investigator Department of Biomedical Engineering
Davis Heart and Lung Research Institute
Biomedical Research Tower
340 C, D, 460 W 12th Ave (lab)
275 Bevis Hall
1080 Carmack Road (Office)
Columbus, OH, 43210
In 2014, we applied a high-speed imaging platform and a resistive force theory (RFT) based model to investigate multi-flagellated propulsion, using T. foetus as an example. We discovered that T. foetus has distinct flagellar beating motions for linear swimming and turning, similar to the ‘run and tumble’ strategies observed in bacteria and Chlamydomonas. It was found that the curvatures of the anterior flagella do not decrease monotonically along their lengths, confirming the ciliary waveform of these flagella. It was also discovered that the propulsive force of T. foetus was similar to that of sperm and Chlamydomonas, indicating that multi-flagellated propulsion does not necessarily contribute to greater thrust generation, and may have evolved for greater manoeuvrability or sensing. The findings were published in Journal of The Royal Society Interface.
In 2014, an infusion-dialysis based procedure is developed by our group for isolating nanoparticles from green tea. The potential of these tea nanoparticles as a multifunctional nanocarrier for cancer therapy in vitro is further explored. The tea nanoparticles showed enhancement of the in vitro secretion of cytokines IL-6, TNF-a, and G-CSF, as well as the chemokines RANTES, IP-10, MDC from mouse macrophages RAW264.7, indicating an immunostimulatory effect. As a nanocarrier, the TNPs are able to form complexes with doxorubicin (DOX). Further the DOX-loaded tea nanopartcles increase the cellular DOX uptake, compared to free DOX, leading to higher cytotoxicity in the A549 human lung cancer and MCF-7 breast cancer cells. More importantly, the DOX-loaded tea nanoparticles significantly increase the DOX uptake and cytotoxicity in MCF-7/ADR multidrug resistant breast cancer cells. The work was published in Journal of Biomedical Nanotechnology.
In 2013, our findings published in Journal of The Royal Society Interface concluded that the nanoparticles found in the high-strength adhesive secreted from English ivy are proteinaceous, providing further insight regarding their contribution to the enhanced adhesive properties exhibited by this surface climbing plant.
In 2012, we developed a method to produce nanoparticles from Arthrobotrys oligospora, a carnivorous fungus known for creating a three dimensional network of traps to capture its prey. These nanoparticles have shown promise as a potential drug delivery vehicle that can be used for cancer immunochemotherapy. Our findings were published in Advanced Functional Materials. News about this research can be found here.
In 2012, we discovered that curved swimming trajectories of the whirligig beetles were more energy efficient relative to linear trajectories, when considering the overall distance traveled per leg stroke. This observation provides one source of evidence as to why these types of trajectories are more often observed in nature. This work was published in PLoS Computational Biology. News about this research can be found here.
In 2008, English ivy inspired our discovery that it secretes a high-strength adhesive containing nanoparticles, which have been shown to aid in its ability to climb many different surfaces. This work was published by Nano Letters and was featured in multiple media and press releases.
D.Sc., 2000, Washington University in St. Louis, USA.
Ph.D., 1996, Zhejiang University, P. R. China.
MS in BioEngineering, 2007, Stanford University, CA, USA.
MS in Electrical Engineering, 2007, Stanford University, CA, USA.
MS in Mechanical Engineering, 1994, Zhejiang University, P. R. China.
B.Eng in Mechanical Engineering, 1990, Zhejiang University, P. R. China.
Honors and Awards
Research Fellow Award. College of Engineering. The University of Tennessee, 2013.
Young Investigator Award. Office of Naval Research. Department of Defense, 2011.
Research Fellow Award. College of Engineering. The University of Tennessee, 2011.
Innovation Merit Award. Life Sciences & Chemical Analysis Division, Agilent Technologies, 2005.
Boeing Distinguished Speaker. The University of Missouri--Rolla, 2004.
Early Career Award (Government/Industry). IEEE Robotics and Automation Society, 2003.
2014 - Present. Professor and Investigator, Department of Biomedical Engineering and Davis Heart and Lung Research Institute. The Ohio State University, Columbus, OH 43201, USA.
2008 - 2013. Associate Professor, Department of Mechanical, Aerospace and Biomedical Engineering. The University of Tennessee, Knoxville, TN 37996, USA.
2001 - 2007. Research and Development (full time). Bio-chip fabrication, lab-on-a-chip molecular diagnosis and bio-instrumentation. Life Science and Chemical Analysis Division, Agilent Technologies, California, USA.
Department of Biomedical Engineering. The Ohio State University, Columbus, Ohio 43201